Harnessing indel history statistics for molecular biomarker detection in viral genomes

Description

Indels amount to ~25% of genomic variation and can serve as molecular markers. Standard bioinformatic pipelines lack analyses of indel dynamics. Recently my team developed indel-aware methods for inferring molecular evolutionary history. Together with the Swiss HIV Cohort Study we will develop indel history statistics for detecting indel biomarkers related to immune escape and drug resistance.