Zurich University
of Applied Sciences

Simulation-based-process-development of an industrial scale technology for temperature stable vaccines

LaPaSim

Description

Within LaPaSim we will develop the Multiphysics simulation models for an industrial unit of a novel ambient temperature drying tech-nology (LaminarPace) enabling dry powder and temperature-stable vaccines, at an industrial scale and ready for integration in commercial production. An innovative Simulation-based-Process-Design approach will be elaborated to consider the complex Multiphysics coupling of mass-, heat- and momentum- transport mechanisms, lifting the technology from the pilot- to an optimised and validated industrial scale. Thus, we will ultimately provide an opportunity to crack the cold chain and increase the worldwide vaccine supply.

Simulation results from the preliminary 3D numerical simulation model (OpenFOAM-10). Top: Mass fraction of H2O. Bottom: Mass fraction profile at multiple heights of the unit.

Key data

Projectlead

Prof. Dr. Gernot Kurt Boiger

Deputy Projectlead

Alain Schubiger

Project team

Bercan Siyahhan, Marco Hostettler, Jhimy Michel Rivero

Project partners

ZICCUM AB

Project status

completed, 02/2023 - 07/2026

Institute/Centre

Institute of Computational Physics (ICP)

Funding partner

Eurostars / Projekt Nr. E!2,199 LaPaSim

Research and Development

ZHAW President’s Office
Gertrudstrasse 15
8401 Winterthur

+41 (0) 58 934 67 70
research@zhaw.ch

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