Repeat protein Function, Refinement, Annotation and Classification of Topologies (REFRACT)
Description
REFRACT is an international consortium aiming to extend our knowledge on the mechanism of tandem repeat protein (TRP) function and evolution, establishing a common classification and best practices. Starting from available state of the art computational tools and databases, it aims to drive a new level of TRP characterization leveraging the complementary expertise of institutions in Europe and Latin America.
Key data
Projectlead
Prof. Dr. Maria Anisimova, Prof. Silvio Tosatto
Project team
Matteo Delucchi
Project partners
European Molecular Biology Laboratory EMBL; Centre national de la recherche scientifique CNRS; Johannes Gutenberg-Universität Mainz; Spanish National Research Council; Stockholm University; National University of Quilmes; National University of La Plata; Pontifical Catholic University of Peru; Cayetano Heredia University; Pontifical Catholic University of Chile; Centro de Ingeniería Genética y Biotecnología de Cuba; National Autonomous University of Mexico; University of Cauca; Centro De Investigacion Cientifica Caucaseco Ltda
Project status
completed, 04/2019 - 04/2025
Institute/Centre
Institute of Computational Life Sciences (ICLS)
Funding partner
Horizon 2020 / Projekt Nr. 823886
Further documents and links
Publications
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Multicancer analyses of short tandem repeat variations reveal shared gene regulatory mechanisms
2025 Xia, Feifei; Verbiest, Max Adriaan; Lundström, Oxana; Bilgin Sonay, Tugçe; Baudis, Michael; Anisimova, Maria
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Short tandem repeat mutations regulate gene expression in colorectal cancer
2024 Verbiest, Max; Lundström, Oxana; Xia, Feifei; Baudis, Michael; Bilgin Sonay, Tugçe; Anisimova, Maria
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A novel hypervariable variable number tandem repeat in the dopamine transporter gene (SLC6A3)
2023 Apsley, Abner T.; Domico, Emma R.; Verbiest, Max A.; Brogan, Carly A.; Buck, Evan R.; Burich, Andrew J.; Cardone, Kathleen M.; Stone, Wesley J.; Anisimova, Maria; Vandenbergh, David J.
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Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species
2022 Verbiest, Max; Maksimov, Mikhail; Jin, Ye; Anisimova, Maria; Gymrek, Melissa; Bilgin Sonay, Tugce
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TRAL 2.0 : tandem repeat detection with circular profile hidden Markov models and evolutionary aligner
2021 Delucchi, Matteo; Näf, Paulina; Bliven, Spencer; Anisimova, Maria
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A new census of protein tandem repeats and their relationship with intrinsic disorder
2020 Delucchi, Matteo; Schaper, Elke; Sachenkova, Oxana; Elofsson, Arne; Anisimova, Maria
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A new census of protein tandem repeats and their relationship with intrinsic disorder room
2020 Delucchi, Matteo
School of Life Sciences and Facility Management
Schloss
8820 Wädenswil