PD Dr. René Köffel
PD Dr. René Köffel
ZHAW
School of Life Sciences and Facility Management
Hämatologie & Immunologie
Work at ZHAW
Position
Head of the Hematology and Immunology group, Lecturer for Bachelor studies in Biomedical Laboratory Diagnostics
Network
Membership of networks
ORCID digital identifier
Social media
Projects
Biological testing and development of a wound healing product / Project leader / completed
Selected publications
- Mukhopadhyay, A. et al. (2025) Pneumolysin nanopores with 20 nm inner diameter to characterize the size and shape of Tau oligomers. bioRxiv. doi: 10.1101/2025.02.07.637128.
- Bauer, T. et al. (2025) 'Vitamin K supports TGF-β1 depended in vitro human Langerhans cell differentiation and function via Axl', Frontiers in Immunology, 16(1509228). doi: 10.3389/fimmu.2025.1509228.
Publications
Articles in scientific journal, peer-reviewed
Bauer, T. et al. (2025) 'Vitamin K supports TGF-β1 depended in vitro human Langerhans cell differentiation and function via Axl', Frontiers in Immunology, 16(1509228). doi: 10.3389/fimmu.2025.1509228.
Written conference contributions, peer-reviewed
Köffel, R. et al. (2026) 'Acoustic bioactivation of autologous blood : a biophysical platform for advanced wound repair', in Symposium on Advanced Wound Care (SAWC) Spring in collaboration with the Wound Healing Society (WHS), Charlotte, NC, USA, 8-12 April 2026. Wound Healing Society.
Other publications
Mukhopadhyay, A. et al. (2025) Pneumolysin nanopores with 20 nm inner diameter to characterize the size and shape of Tau oligomers. bioRxiv. doi: 10.1101/2025.02.07.637128.
Oral conference contributions and abstracts
Mukhopadhyay, A. et al. (2025) 'Fingerprinting folded proteins with large-diameter pneumolysin nanopore', in Biophysical Journal. Cell Press, p. 501a. doi: 10.1016/j.bpj.2024.11.2637.
Other publications
- Publications total
- Thomas Bauer, Susanne Richter-Eder, Nighat Yasmin, Jennifer Jurkin, René Köffel, Herbert Strobl. Vitamin K supports TGF-β1 depended in vitro human Langerhans cell differentiation and function via Axl. Front Immunol. 2025 Feb 18:16:1509228.
- Anasua Mukhopadhyay; Wachara Chanakul; Yu-Noel Larpin; Saurabh Awasthi; Anna D. Protopopova; René Köffel; Alessandro Ianiro; Michael Mayer. Pneumolysin nanopores with 20 nm inner diameter to characterize the size and shape of Tau oligomers. bioRxiv 2025.02.07.637128; doi: https://doi.org/10.1101/2025.02.07.637128.
- Besançon H, Larpin Y, Babiychuk VS, Köffel R, Babiychuk EB. Engineered Liposomes Protect Immortalized Immune Cells from Cytolysins Secreted by Group A and Group G Streptococci. Cells. 2022 Jan 5;11(1):166. doi: 10.3390/cells11010166. PMID: 35011729; PMCID: PMC8749993.
- Besançon H, Babiychuk V, Larpin Y, Köffel R, Schittny D, Brockhus L, Hathaway LJ, Sendi P, Draeger A, Babiychuk E. Tailored liposomal nanotraps for the treatment of Streptococcal infections. J Nanobiotechnology. 2021 Feb 15;19(1):46. doi: 10.1186/s12951-021-00775-x. PMID: 33588835; PMCID: PMC7885208.
- Borek I, Köffel R, Feichtinger J, Spies M, Glitzner-Zeis E, Hochgerner M, Sconocchia T, Krump C, Tam-Amersdorfer C, Passegger C, Benezeder T, Tittes J, Redl A, Painsi C, Thallinger GG, Wolf P, Stary G, Sibilia M, Strobl H. BMP7 aberrantly induced in the psoriatic epidermis instructs inflammation-associated Langerhans cells. J Allergy Clin Immunol. 2020 Apr;145(4):1194-1207.e11. doi: 10.1016/j.jaci.2019.12.011. Epub 2019 Dec 21. PMID: 31870764.
- Larpin Y, Besançon H, Iacovache MI, Babiychuk VS, Babiychuk EB, Zuber B, Draeger A, Köffel R. Bacterial pore-forming toxin pneumolysin: Cell membrane structure and microvesicle shedding capacity determines differential survival of cell types. FASEB J. 2020 Jan;34(1):1665-1678. doi: 10.1096/fj.201901737RR. Epub 2019 Dec 4. PMID: 31914676.
- Köffel R, Wolfmeier H, Larpin Y, Besançon H, Schoenauer R, Babiychuk VS, Drücker P, Pabst T, Mitchell TJ, Babiychuk EB, Draeger A. Host-Derived Microvesicles Carrying Bacterial Pore-Forming Toxins Deliver Signals to Macrophages: A Novel Mechanism of Shaping Immune Responses. Front Immunol. 2018 Jul 27;9:1688. doi: 10.3389/fimmu.2018.01688. PMID: 30100903; PMCID: PMC6072879.