Dr. Stefano Agnello

Projects

• Targeting the innate immune system for Multiple Sclerosis / Team member / ongoing
• Alzheimer's dementia / Team member / ongoing
• Small molecules targeting CD93-signaling for the treatment of acute myeloid leukemia / Team member / ongoing
• Innovative Immunotherapy Approach / Team member / completed
• Developing novel and effective therapies for treatment of childhood brain cancers / Team member / completed
• Inflammasome inhibitors - Development of new inhibitors / Team member / completed

Publications

Articles in scientific journal, peer-reviewed

• Brand, M., Wang, L., Agnello, S., Gazzola, S., Gall, F., Raguž, L., Kaiser, M., Schmidt, R. S., Ritschl, A., Jelk, J., Hemphill, A., Mäser, P., Bütikofer, P., Adams, M., & Riedl, R. (2021). Antiprotozoische Struktur‐Aktivitäts‐Beziehungen von synthetischen Leucinostatin‐Derivaten und Aufklärung ihres Wirkprinzips. Angewandte Chemie, 133(28), 15741–15749. https://doi.org/10.1002/ange.202102153
• Brand, M., Wang, L., Agnello, S., Gazzola, S., Gall, F., Raguž, L., Kaiser, M., Schmidt, R. S., Ritschl, A., Jelk, J., Hemphill, A., Mäser, P., Bütikofer, P., Adams, M., & Riedl, R. (2021). Antiprotozoal structure–activity relationships of synthetic leucinostatin derivatives and elucidation of their mode of action. Angewandte Chemie: International Edition, 60(28), 15613–15621. https://doi.org/10.1002/anie.202102153
• Agnello, S., Brand, M., Chellat, M., Gazzola, S., & Riedl, R. (2018). A Structural view on medicinal chemistry strategies against drug resistance. Angewandte Chemie, 58(11), 3300–3345. https://doi.org/10.1002/anie.201802416
• Agnello, S., Brand, M., Chellat, M., Gazzola, S., & Riedl, R. (2018). Eine strukturelle Evaluierung medizinalchemischer Strategien gegen Wirkstoffresistenzen. Angewandte Chemie, 131(11), 3336–3383. https://doi.org/10.1002/ange.201802416
• Abu El Asrar, R., Margamuljana, L., Abramov, M., Bande, O., Agnello, S., Jang, M., & Herdewijn, P. (2017). Enzymatic incorporation of modified purine nucleotides in DNA. ChemBioChem, 18(24), 2408–2415. https://doi.org/10.1002/cbic.201700393

Patents and patent applications

• Agnello, Stefano; Adams, Michael; Kaiser, Marcel; Mäser, Pascal; Urban, Alexander; Raguz, Luka; Riedl, Rainer,

  2018.

  Antiprotozoal compounds.

  Patent number EP3345917 A1

  (2018-07-11)

  .

  Available from: https://worldwide.espacenet.com/patent/search?q=pn%3DEP3345917A1

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