Thomas Fischer

Persönliches Profil

Tätigkeit an der ZHAW

Wissenschaftlicher Mitarbeiter am Institut für Chemie und Biologische Chemie, Fachstelle Organische Chemie

www.zhaw.ch/icbt/organic-and-medicinal-chemistry/

Aus- und Fortbildung

2009 - 2011: Masterstudium (MSc) in "Chemistry for the Life Sciences", Zürcher Hochschule für Angewandte Wissenschaften (ZHAW), Wädenswil
2005 - 2008: Bachelorstudium (BSc) in Chemie, Zürcher Hochschule für Angewandte Wissenschaften (ZHAW), Winterthur

Projekte

• Protease-Inhibitoren gegen SARS-CoV-2 / Teammitglied / Projekt laufend
• Entwicklung neuer Therapieansätze zur Behandlung von Krebs / Teammitglied / Projekt abgeschlossen
• Modulatoren der MMP-Hemopexin-Domäne / Teammitglied / Projekt abgeschlossen
• Neue Antibiotika: RNA-Polymerase-Inhibitoren / Teammitglied / Projekt abgeschlossen
• Dynamic combinatorial chemistry in drug discovery / Teammitglied / Projekt abgeschlossen
• Kinetische Struktur-Aktivitäts-Beziehungen und röntgenkristallographische Bestimmung des Bindungsmodus von niedermolekularen Wirkstoffmolekülen / Teammitglied / Projekt abgeschlossen

Publikationen

• Fischer, Thomas; Riedl, Rainer,

  2022.

  Paracelsus' legacy in the faunal realm : drugs deriving from animal toxins.

  Drug Discovery Today.

  27(2), S. 567-575.

  Verfügbar unter: https://doi.org/10.1016/j.drudis.2021.10.003

• Zizzari, Alessandra Tania; Pliatsika, Dimanthi; Gall, Flavio; Fischer, Thomas; Riedl, Rainer,

  2021.

  New perspectives in oral peptide delivery.

  Drug Discovery Today.

  26(4), S. 1097-1105.

  Verfügbar unter: https://doi.org/10.1016/j.drudis.2021.01.020

• Fischer, Thomas; Riedl, Rainer,

  2020.

  Challenges with matrix metalloproteinase inhibition and future drug discovery avenues.

  Expert Opinion on Drug Discovery.

  16(1), S. 75-88.

  Verfügbar unter: https://doi.org/10.1080/17460441.2020.1819235

• Fischer, Thomas; Gazzola, Silvia; Riedl, Rainer,

  2019.

  Approaching target selectivity by de novo drug design.

  Expert Opinion on Drug Discovery.

  14(8), S. 791-803.

  Verfügbar unter: https://doi.org/10.1080/17460441.2019.1615435

• Fischer, Thomas; Senn, Nicole; Riedl, Rainer,

  2019.

  Design and structural evolution of matrix metalloproteinase inhibitors.

  Chemistry – A European Journal.

  25(34), S. 7960-7980.

  Verfügbar unter: https://doi.org/10.1002/chem.201805361

• Fischer, Thomas; Koulas, Symeon M.; Tsagkarakou, Anastasia S.; Kyriakis, Efthimios; Stravodimos, George A.; Skamnaki, Vassiliki T.; Liggri, Panagiota G.V.; Zographos, Spyros E.; Riedl, Rainer; Leonidas, Demetres D.,

  2019.

  High consistency of structure-based design and x-ray crystallography : design, synthesis, kinetic evaluation and crystallographic binding mode determination of biphenyl-N-acyl-β-D-glucopyranosylamines as glycogen phosphorylase inhibitors.

  Molecules.

  24(7), S. 1322.

  Verfügbar unter: https://doi.org/10.3390/molecules24071322

• Fischer, Thomas; Riedl, Rainer,

  2019.

  Inhibitory antibodies designed for matrix metalloproteinase modulation.

  Molecules.

  24(12), S. 2265.

  Verfügbar unter: https://doi.org/10.3390/molecules24122265

• Fischer, Thomas; Riedl, Rainer,

  2017.

  Cover picture : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor (ChemistryOpen 2/2017).

  ChemistryOpen.

  6(2), S. 165.

  Verfügbar unter: https://doi.org/10.1002/open.201700043

• Fischer, Thomas; Riedl, Rainer,

  2017.

  Cover profile : targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor.

  ChemistryOpen.

  6(2), S. 167.

  Verfügbar unter: https://doi.org/10.1002/open.201700042

• Fischer, Thomas; Riedl, Rainer,

  2017.

  Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor.

  Molecules.

  22(9).

  Verfügbar unter: https://doi.org/10.3390/molecules22091548

• Fischer, Thomas; Riedl, Rainer,

  2017.

  Targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor.

  ChemistryOpen.

  6(2), S. 192-195.

  Verfügbar unter: https://doi.org/10.1002/open.201600158

• Fischer, Thomas; Riedl, Rainer,

  2016.

  Molecular recognition of the catalytic zinc(II) ion in MMP-13 : structure-based evolution of an allosteric inhibitor to dual binding mode inhibitors with improved lipophilic ligand efficiencies.

  International Journal of Molecular Sciences.

  17(3/314).

  Verfügbar unter: https://doi.org/10.3390/ijms17030314

• Fischer, Thomas; Riedl, Rainer,

  2013.

  Strategic targeting of multiple water-mediated interactions : a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors.

  ChemMedChem.

  8(9), S. 1457-1461.

  Verfügbar unter: https://doi.org/10.1002/cmdc.201300278

• Fischer, Thomas; Riedl, Rainer,

  2012.

  Design, synthesis and biological testing of novel MMP-inhibitors [Poster].

  In:

  Fall Meeting 2012 of the Swiss Chemical Society, Zurich, 13 September 2012.

• Riedl, Rainer; Fischer, Thomas,

  2012.

  Structure based design and synthesis of novel MMP inhibitors [Poster].

  In:

  19th EuroQSAR: «Knowledge Enabled Ligand Design», Vienna, Austria, 26-30 August 2012.

• Riedl, Rainer; Fischer, Thomas; Züger, Patrik; Brand, Michael,

  2011.

  Structure based design and synthesis of novel MMP inhibitors [Poster].

  In:

  Fall Meeting 2011 of the Swiss Chemical Society, Lausanne, 9 September 2011.

• Riedl, Rainer; Fischer, Thomas,

  2010.

  Fragment based scaffold hopping in drug discovery [Poster].

  In:

  Fall Meeting 2012 of the Swiss Chemical Society, Zurich, 16 September 2010.

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