Prof. Dr. Sabina Gerber

Personal profile

Management role

Head, Centre for Biochemistry and Bioanalytics

Position at the ZHAW

Lecturer in Bioanalytics and Biochemistry

www.zhaw.ch/en/lsfm/institutes-centres/icbt/biochemistry-and-bioanalytics/bioanalytics/

Projects

• Endotoxin Quantification / Project leader / Project ongoing
• Molecular mechanism of bacteriophage tail spike proteins in bacterial infection / Project leader / Project completed
• EuroBioTox – European programme for the establishment of validated procedures for the detection and identification of biological toxins / Project leader / Project completed

Publications before appointment at the ZHAW

Patent Inventorship: IMMUNOGENIC COMPOSITION published as WO2019/121924, PCT/EP2018/085854
Issued Jun 27, 2019
Engineered Staphylococcus aureus HIa proteins with reduced tendency to aggregate, enhanced protein stability and yield. Further modification of Hla proteins with glycosylation site consensus sequences and Staphylococcus aureus saccharide antigens.


Patent Inventorship: IMMUNOGENIC COMPOSITION published as WO2019/121926, PCT/EP2018/085857
Issued Jun 27, 2019
Engineered Staphylococcus aureus ClfA proteins further modified with glycosylation site consensus sequences and Staphylococcus aureus saccharide antigens.


Patent Inventorship: IMMUNOGENIC COMPOSITION published as WO2017/216286, PCT/EP2017/064659
Issued Dec 21, 2017
Engineered Streptococcus pneumoniae pneumolysin proteins with further modifications including glycosylation site consensus sequences and linked Streptococcus pneumoniae saccharide antigens.


Structure and mechanism of an active lipid-linked oligosaccharide flippase
Perez C, Gerber S, Boilevin J, Bucher M, Darbre T, Aebi M, Reymond JL, Locher KP
Nature. 2015 Aug 27;524(7566):433-8


On the efficiency of NHS ester cross-linkers for stabilizing integral membrane protein complexes
Chen F, Gerber S, Korkhov VM, Mireku S, Bucher M, Locher KP, Zenobi R
J Am Soc Mass Spectrom. 2015 Mar;26(3):493-8


Antibodies to Staphylococcus aureus serotype 8 capsular polysaccharide react with and protect against serotype 5 and 8 isolates
Park S, Gerber S, Lee JC
Infect Immun. 2014 Dec;82(12):5049-55


A catalytically essential motif in external loop 5 of the bacterial oligosaccharyltransferase PglB
Lizak C*, Gerber S*, Zinne D, Michaud G, Schubert M, Chen F, Bucher M, Darbre T, Zenobi R, Reymond JL, Locher KP
J Biol Chem. 2014 Jan 10;289(2):735-46
*equal contribution


Unexpected reactivity and mechanism of carboxamide activation in bacterial N-linked protein glycosylation
Lizak C*, Gerber S*, Michaud G, Schubert M, Fan YY, Bucher M, Darbre T, Aebi M, Reymond JL, Locher KP
Nat Commun. 2013;4:2627
*equal contribution


High-mass matrix-assisted laser desorption ionization-mass spectrometry of integral membrane proteins and their complexes
Chen F, Gerber S, Heuser K, Korkhov VM, Lizak C, Mireku S, Locher KP, Zenobi R
Anal Chem. 2013 Apr 2;85(7):3483-8


Mechanism of bacterial oligosaccharyltransferase: in vitro quantification of sequon binding and catalysis
Gerber S*, Lizak C*, Michaud G, Bucher M, Darbre T, Aebi M, Reymond JL, Locher KP
J Biol Chem. 2013 Mar 29;288(13):8849-61
*equal contribution


X-ray structure of a bacterial oligosaccharyltransferase
Lizak C, Gerber S, Numao S, Aebi M, Locher KP
Nature. 2011 Jun 15;474(7351):350-5


Structural basis of trans-inhibition in a molybdate/tungstate ABC Transporter
Gerber S, Comellas-Bigler M, Goetz BA, Locher KP
Science. 2008 Jul 11;321(5886):246-50


Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA
Mayer M, Lang PT, Gerber S, Madrid PB, Pinto IG, Guy RK, James TL
Chem Biol. 2006 Sep;13(9):993-1000

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