Prof. Dr. Sabina Gerber

Work at ZHAW

Position

Lecturer in Biochemistry and Bioanalytics, Head Center of Microbiology, Molecular Biology and Biochemistry

Network

ORCID digital identifier

ORCID ID: 0009-0005-8875-4986

Projects

• Local brain retention for better brain cancer drugs / Project leader / ongoing
• Development of a method for botulism diagnostics / Project leader / ongoing
• Development and bioanalytics of therapeutic mAbs and ADC / Project leader / ongoing
• Bioanalytics for the development of biopharmaceuticals / Project leader / ongoing
• Catabolite Identification and Quantification / Project leader / ongoing
• Endotoxin Quantification / Project leader / completed
• Molecular Mechanism of Host Infection by Bacteriophages / Project leader / completed
• Bioanalytics of multispecific therapeutic antibodies / Project leader / completed
• Enhancement the sensitivity for the pharmacokinetics of a clinical trial / Project leader / completed
• Development of therapeutic mAb and ADCs / Project leader / completed
• Pharmakokinetics for a clinical trial / Project leader / completed
• Molecular mechanism of bacteriophage tail spike proteins in bacterial infection / Project leader / completed
• Mass spectrometric analyses of DARPins / Project leader / completed
• Method development for the quantification of a biopharmaceutical against an auto-immune disease / Project leader / completed
• ELISA Development for the quantification of anti-drug IgG1 antibodies in animal sera / Project leader / completed
• Bioanalytics of vaccine bioconjugate candidates / Project leader / completed
• Method development for the early product quantification / Project leader / completed
• EuroBioTox – European programme for the establishment of validated procedures for the detection and identification of biological toxins / Project leader / completed

Publications

• Josuran, Roland; Wenger, Andreas; Worbs, Sylvia; Kampa, Bettina; Rummel, Andreas; Dorner, Brigitte G.; Gerber, Sabina,

  2025.

  N-Glycosylation profile of abrin certified EU reference material.

  Toxins.

  17(3), pp. 108.

  Available from: https://doi.org/10.3390/toxins17030108

• Josuran, Roland; Wenger, Andreas; Müller, Christian; Kampa, Bettina; Worbs, Sylvia; Dorner, Brigitte G.; Gerber, Sabina,

  2024.

  Glycan profile and sequence variants of certified ricin reference material and other ricin samples yield unique molecular signature features.

  Toxins.

  16(6), pp. 243.

  Available from: https://doi.org/10.3390/toxins16060243

Publications before appointment at the ZHAW

• Perez C, Gerber S, Boilevin J, Bucher M, Darbre T, Aebi M, Reymond JL, Locher KP. “Structure and mechanism of a lipid-linked-oligosaccharide flippase” Nature 2015;524(7566):433-8.
• Chen F, Gerber S, Korkhov VM, Mireku S, Bucher M, Locher KP, Zenobi R. “On the Efficiency of NHS Ester Cross-Linkers for Stabilizing Integral Membrane Protein Complexes” J Am Soc Mass Spectrom 2015;26(3):493-8.
• Park S, Gerber S, Lee JC. “Antibodies to Staphylococcus aureus Serotype 8 Capsular Polysaccharide React with and Protect against Serotype 5 and 8 Isolates” Infect Immun 2014;82(12):5049-55.
• Lizak C*, Gerber S*, Zinne D, Michaud G, Schubert M, Chen F, Bucher M, Darbre T, Zenobi R, Reymond JL, Locher KP “A catalytically essential motif in external loop 5 of the bacterial oligosaccharyltransferase PglB” J Biol Chem 2014;289(2):735-46. *equal contribution
• Lizak C*, Gerber S*, Michaud G, Schubert M, Fan YY, Bucher M, Darbre T, Aebi M, Reymond JL, Locher KP “Unexpected reactivity and mechanism of carboxamide activation in bacterial N-linked protein glycosylation”, Nat Commun 2013;4:2627. *equal contribution
• Chen F, Gerber S, Heuser K, Korkhov VM, Lizak C, Mireku S, Locher KP, Zenobi R “High-mass matrix-assisted laser desorption ionization-mass spectrometry of integral membrane proteins and their complexes”, Anal Chem 2013, 85(7):3483-8.
• Gerber S*, Lizak C*, Michaud G, Bucher M, Darbre T, Aebi M, Reymond JL, Locher KP. “Mechanism of bacterial oligosaccharyltransferase: in vitro quantification of sequon binding and catalysis”, J Biol Chem 2013 288(13):8849-61. *equal contribution
• Lizak C, Gerber S, Numao S, Aebi M, Locher KP. “X-ray structure of a bacterial oligosaccharyltransferase”, Nature, 2011, 474 (7351), 350-355.
• Gerber S*, Comellas-Bigler M*, Goetz BA, Locher KP. “Structural basis of trans-inhibition in a molybdate/tungstate ABC transporter” Science, 2008, 321 (5886), 246-250. *equal contribution
• Mayer M, Downing PT, Gerber S, Madrid PB, Pinto IG, Guy RK, James TL. “Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA” Chem Biol, 2006, 13(9), 993-1000.

Other publications

• Patent application: METHODS FOR PROTEIN PURIFICATION - WO 20/260436
• Patent application: IMMUNOGENIC COMPOSITION - WO 19/121924 Granted in the US, US11286283
• Patent application: IMMUNOGENIC COMPOSITION - WO 19/121926 Granted in the US, US11819544

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