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New antileishmanial and antitrypanosomal drugs

At a glance

  • Project leader : Prof. Dr. Rainer Riedl
  • Project team : Dr. Stefano Agnello, Dr. Michael Brand, Flavio Gall, Dr. Silvia Gazzola, Luka Raguz
  • Project budget : CHF 2'043'672
  • Project status : completed
  • Funding partner : CTI (KTI-Projekt / Projekt Nr. 19208.1 PFLS-LS)
  • Project partner : BACOBA AG
  • Contact person : Rainer Riedl


The aim is to develop a natural product derived LEAD compound with unrivalled potency against a parasitic disease into a clinical drug candidate, through preclinical development. This includes the establishment of a detailed structure-activity relationship (SAR), medicinal chemistry and organic synthesis, ADME-Tox optimization, formulation, and in vivo studies.