Large-scale implementation of an optimum technology for high-productivity processes with recombinant methylotrophic yeasts

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Projektleiter/in: Prof. Dr. Karin Kovar

Projektbeginn: 01.10.2005


Recombinant Pichia pastoris is an emerging competitor in the manufacture of biopharmaceuticals, especially where secreted proteins are concerned. Based on systematic physiological studies, an innovative technology (procedures) for robust high-productivity processes will be established and scaled-up. Furthermore, a compendium of the knowledge gathered, inter alia regarding the best practice on mixed substrate cultivations and physiological state monitoring, will be made available to the community concerned.