A DNA repair protein as a target in cancer therapy

At a glance

Project leader : Dr. Kerstin Gari
Project team : Laure-Anne Bickel
Project status : ongoing
Funding partner : Internal

Description

DNA repair proteins are interesting targets in cancer therapy. The objective of this project is the identification of a suitable target site in a DNA repair protein with the long-term goal of developing inhibitors against this protein.

Publications

Lee, Wei Ting C.; Yin, Yandong; Morten, Michael J.; Tonzi, Peter; Gwo, Pam Pam; Odermatt, Diana C.; Modesti, Mauro; Cantor, Sharon B.; Gari, Kerstin; Huang, Tony T.; Rothenberg, Eli,

2021.

Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling.

Nature Communications.

12(1), pp. 2525.

Available from: https://doi.org/10.1038/s41467-021-22830-9

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