Section of Metabolic Tissue Engineering
«Based on applied matrix biology and biophysics (macromolecular crowding, supramolecular aggregates) we develop metabolically active human models like fatty tissue and skeleton muscle.»
The focus of our research is the construction of three-dimensional tissue cultures using human primary cells. We have been applying the methods of tissue engineering for over 10 years to various tissue types such as bone, cartilage and intervertebral discs, connective tissue and skin, the liver and the pancreas. These in vitro tissues and the use of various technologies provide the basis for many diverse objectives and applications.
Our developments are used in areas such as
- Cell culture technology: automated processes, consideration of biomechanical aspects and bioprinting
- Biomaterials and implants: development, characterisation, surface modification and in vitro studies
- Medicine: regenerative, cell-based therapies and clinical trials
- Drug development: Cultivation and use of organotypic models for substance evaluation
Our research laboratories provide a modern infrastructure and methodological expertise.
We offer our project partners a wide range of opportunities for cooperation. Customer-specific concerns are the principal focus of Bachelor's and Master's theses, directly funded collaborations, and CTI projects.
Raghunath, Michael; Wong, Yuan Sy; Farooq, Muhammad; Gee, Ruowen,
Biochemical and Biophysical Research Communications.
378(4), pp. 766-771.
Available from: https://doi.org/10.1016/j.bbrc.2008.11.127
Wang, Z.; Chen, C.; Finger, S. N.; Kwajah M.M, S. d/o; Jung, M.; Schwarz, H.; Swanson, N.; Lareu, R. R.; Raghunath, M.,
The European Respiratory Journal.
34(1), pp. 145-155.
Available from: https://doi.org/10.1183/09031936.00084808
Chen, C.Z.C.; Fish, P.V.; Peng, Y.X.; Wang, Z.B.; Kaar, J.L.; Koepsel, R.R.; Russell, A.J .; Lareu, R.R.; Raghunath, M.,
British Journal of Pharmacology.
158(5), pp. 1196-1209.
Available from: https://doi.org/10.1111/j.1476-5381.2009.00387.x
Zeugolis, D. I.; Li, B.; Lareu, R.R.; Chan, C.K.; Raghunath, M.,
Journal of Biomaterials Science, Polymer Edition.
19(10), pp. 1307-1317.
Available from: https://doi.org/10.1163/156856208786052344
Zeugolis, Dimitrios I.; Khew, Shih T.; Yew, Elijah S.Y.; Ekaputra, Andrew K.; Tong, Yen W.; Yung, Lin-Yue L.; Hutmacher, Dietmar W.; Sheppard, Colin; Raghunath, Michael,
29(15), pp. 2293-2305.
Available from: https://doi.org/10.1016/j.biomaterials.2008.02.009