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Section Biochemistry

«Targeted therapies that take into account the molecular features of a tumour are of increasing importance in cancer treatment.»

Dr. Kerstin Gari, Head of Section

Research

Cancer cells commonly display a high level of genome instability, which frequently goes along with alterations in the DNA damage response, such as the downregulation of certain DNA repair factors and the dependence on other, alternative, DNA repair pathways. Such a dependence renders cancer cells susceptible to the treatment with inhibitors of specific DNA repair factors. Our aim is to identify suitable therapeutic targets and to develop novel inhibitors of DNA repair proteins.

Competencies

Protein engineering, purification and characterisation

Cellular and molecular biology techniques