Sören Werner

Position at the ZHAW

Research Associate Biochemical Engineering

Professional development teaching

Summer School «Cell expansion»

Expertise and research interests

Computational Fluid Dynamics, CFD, Cell Culture Technique, Animal Cells, Plant Cells

Educational background

Study Course Biochemical Engineering, Dipl-Ing., 2006, Technical University Dresden

Membership of networks

• DECHEMA
• SGVC

• Platform Health / Project co-leader / Project ongoing

Articles in scientific journal, peer-reviewed

• Kaiser, Stephan C.; Werner, Sören; Jossen, Valentin; Kraume, Matthias; Eibl, Dieter,

  2017.

  Development of a method for reliable power input measurements in conventional and single-use stirred bioreactors at laboratory scale.

  Engineering in Life Sciences.

  17(5),

  pp. 500-511.

  Available from: https://doi.org/10.21256/zhaw-19650

• Werner, Sören; Greulich, Judith; Geipel, Katja; Steingroewer, Juliane; Bley, Thomas; Eibl, Dieter,

  2014.

  Mass propagation of Helianthus annuus suspension cells in orbitally shaken bioreactors : improved growth rate in single-use bag bioreactors.

  Engineering in Life Sciences.

  14(6),

  pp. 676-684.

  Available from: https://doi.org/10.1002/elsc.201400024

• Klöckner, Wolf; Lattermann, Clemens; Pursche, Franz; Büchs, Jochen; Werner, Sören; Eibl, Dieter,

  2014.

  Time efficient way to calculate oxygen transfer areas and power input in cylindrical disposable shaken bioreactors.

  Biotechnology Progress.

  30(6),

  pp. 1441-1456.

  Available from: https://doi.org/10.1002/btpr.1977

• Werner, Sören; Kaiser, Stephan C.; Kraume, Matthias; Eibl, Dieter,

  2014.

  Computational fluid dynamics as a modern tool for engineering characterization of bioreactors.

  Pharmaceutical Bioprocessing.

  2(1),

  pp. 85-99.

• Werner, Sören; Olownia, Johanna; Egger, Daniel; Eibl, Dieter,

  2013.

  An approach for scale-up of geometrically dissimilar orbitally shaken single-use bioreactors.

  Chemie Ingenieur Technik.

  85(1-2),

  pp. 118-126.

  Available from: https://doi.org/10.1002/cite.201200153

• Werner, Sören; Eibl-Schindler, Regine; Lettenbauer, Christine; Röll, Marcel; Eibl, Dieter; De Jesus, Maria; Zhang, Xiaowei; Stettler, Matthieu; Tissot, Stephanie; Bürkie, Cedric; Broccard, Gilles; Kühner, Markus; Tanner, Rolf; Baldi, Lucia; Hacker, David; Wurm, Florian M.,

  2010.

  Innovative, non-stirred bioreactors in scales form milliliters up to 1000 L for suspension cultures of cells using disposable bags and containers - a Swiss contribution.

  Chimia.

  64(11),

  pp. 819-823.

  Available from: https://doi.org/10.2533/chimia.2010.819

• Kaiser, Stephan; Löffelholz, Christian; Werner, Sören; Eibl, Dieter,

  2010.

  Numerische Fluiddynamik in der Biotechnologie.

  Nachrichten aus der Chemie.

  58(9),

  pp. 897-899.

  Available from: https://doi.org/10.1002/nadc.201075806

• Eibl-Schindler, Regine; Werner, Sören; Eibl, Dieter,

  2009.

  Disposable bioreactors for plant liquid cultures at litre-scale.

  Engineering in Life Sciences.

  9(3),

  pp. 156-164.

  Available from: https://doi.org/10.1002/elsc.200800102

Book parts, peer-reviewed

• Schirmer, Cedric; Müller, Jan; Steffen, Nina; Werner, Sören; Eibl-Schindler, Regine; Eibl, Dieter,

  2020.

  How to produce mAbs in a cube-shaped stirred single-use bioreactor at 200 L scale

  .

  In:

  Pörtner, Ralf, ed.,

  Animal cell biotechnology : methods and protocols.

  New York:

  Springer.

  pp. 169-186.

  Methods in Molecular Biology ; 2095.

  Available from: https://doi.org/10.1007/978-1-0716-0191-4_10

• Werner, Sören; Kraume, Matthias; Eibl, Dieter,

  2011.

  Bag mixing system for single-use

  .

  In:

  Eibl-Schindler, Regine; Eibl, Dieter, eds.,

  Single-use technology in biopharmaceutical manufacture.

  Hoboken:

  Wiley.

  pp. 21-32.

  Available from: https://doi.org/10.1002/9780470909997.ch3

• Löffelholz, Christian; Kaiser, Stephan; Werner, Sören; Eibl, Dieter,

  2011.

  CFD as tool in order to characterize single-use bioreactors

  .

  In:

  Eibl-Schindler, Regine; Eibl, Dieter, eds.,

  Single-use technology in biopharmaceutical manufacture.

  Hoboken:

  Wiley.

  pp. 263-280.

  Available from: https://doi.org/10.1002/9780470909997.ch22

• Eibl-Schindler, Regine; Werner, Sören; Eibl, Dieter,

  2010.

  Bag bioreactor based on wave-induced motion : characteristics and applications

  .

  In:

  Eibl-Schindler, Regine; Eibl, Dieter, eds.,

  Advances in biochemical engineering/biotechnology.

  Berlin:

  Springer.

  pp. 55-87.

  Advances in Biochemical Engineering/Biotechnology ; 115.

  Available from: https://doi.org/10.1007/10_2008_15

Conference contributions, peer-reviewed

• Maschke, Rüdiger; Werner, Sören; Stalder, Mischa; Jossen, Valentin; Eibl, Dieter,

  2016.

  Nutzung von Sensor Spots zur Bestimmung der Gelöstsauerstoffkonzentration in Single-use Systemen im Labormassstab [poster].

  In:

  Institut für Bioprozess- und Analysenmesstechnik, ed.,

  Tagungsband.

  18. Heiligenstädter Kolloquium "Technische Systeme für die Lebenswissenschaft", Heilbad Heiligenstadt, 19.-21. September 2016.

  Winterthur:

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Available from: https://doi.org/10.21256/zhaw-1152

• Meister, Jolanda; Maschke, Rüdiger; Werner, Sören; Abellan, Eric; Stichling, Nicole; Egger, Daniel; Eibl, Dieter,

  2016.

  Cultivation of CHO Cells in Thomson Optimum Growth™ Shake Flasks and Scale-up [poster].

  In:

  Biotech 2016: Biopharmaceutical Manufacturing and Single-Use Technologies.

  Wädenswil:

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Available from: https://doi.org/10.21256/zhaw-1151

• Maschke, Rüdiger; Werner, Sören; Meister, Jolanda; Rohr, Adrian; Abellan, Eric; Eibl, Dieter; Bley, Thomas,

  2016.

  Engineering characterization of Thomson Optimum Growth™ shake flasks with optimized geometry [poster].

  In:

  DECHEMA Himmelfahrtstagung: New Frontiers for Biotech-Processes, Koblenz, Deutschland, 2.-4. Mai 2016.

  Zürcher Hochschule für Angewandte Wissenschaften.

  Available from: https://doi.org/10.21256/zhaw-1141

Other publications

• Olownia, Johanna; Werner, Sören; Eibl, Dieter,

  2013.

  Plant and animal suspension cell cultures : scale-up of geometrically dissimilar orbitally shaken single-use bioreactor.

  Genetic Engineering & Biotechnology News.

  33(21),

  pp. 38-39.

  Available from: https://doi.org/10.1089/gen.33.21.17

• Löffelholz, Christian; Kaiser, Stephan; Werner, Sören; Eibl, Dieter,

  2012.

  Beitrag zur Charakterisierung und zum Einsatz des 50 L Single-Use Bioreactor (S.U.B.) in der biopharmazeutischen Industrie [paper].

  In:

  Heiser, Martin; Sperling, Reinhard, eds.,

  Vortragssammlung / 14. Köthener Rührer-Kolloquium 2011.

  14. Köthener-Rührer-Kolloquium, Köthen, 16. Juni 2011.

  pp. 52-67.

• Kaiser, Stephan; Löffelholz, Christian; Werner, Sören; Eibl, Dieter,

  2011.

  CFD for characterizing standard and single-use stirred cell culture bioreactors

  .

  In:

  Minin, Igor V.; Minin, Oleg V., eds.,

  Computational fluid dynamics : technologies and applications.

  Rijeka, Croatia:

  InTech.

  pp. 97-122.

  Available from: https://doi.org/10.21256/zhaw-1599

• Löffelholz, Christian; Werner, Sören; Eibl, Dieter; Ay, Peter,

  2010.

  Untersuchungen zum Strömungsverhalten des Einweg-Vibromix-Bioreaktors [paper].

  In:

  Egbers, Christoph; Leder, Alfred; Ruck, Bodo; Dopheide, Dietrich, eds.,

  Proceedings der 18. GALA-Fachtagung "Lasermethoden in der Strömungsmesstechnik".

  18. Fachtagung "Lasermethoden in der Strömungsmesstechnik", Cottbus, 7.-9. September 2010.

  Deutsche Gesellschaft für Laser-Anemometrie GALA.

  18.

• Löffelholz, Christian; Werner, Sören; Eibl, Dieter,

  2009.

  Einsatz von CFD zur Bioreaktorcharakterisierung.

  Transfer.

  2009(3).

• Werner, Sören; Nägeli, M.,

  2007.

  Good Vibrations : Charakterisierung eines neuen Einweg-Bioreaktorsystems.

  BioTec.

  2007(3),

  pp. 22-23.

Oral conference contributions and abstracts

• Maschke, Rüdiger; Stalder, Mischa; Werner, Sören; Abellan, Eric; Eibl, Dieter,

  2017.

  Multivariate process transfer and scale-up models for mammalian cell cultures.

  In:

  DECHEMA Himmelfahrtstagung: Models for Developing and Optimising Biotech Production, Neu-Ulm, Deutschland, 22. Mai 2017.

• Löffelholz, Christian; Werner, Sören; Kaiser, Stephan; Husemann, Ute; Tappe, Alexander; Greller, Gerhard; Eibl, Dieter,

  2013.

  Comparative studies of single-use stirred bioreactors by means of traditional methods, CFD and cultivation experiments.

  In:

  ACHEMA Kongress, Frankfurt, Deutschland, 20. Juni 2013.

Publications before appointment at the ZHAW

Pavlov, Atanas; Werner, Sören; Bley, Thomas (2005). Characteristics of Helianthus annuus plant cell culture as a producer of immunologically active exopolysaccharides. Engineering in Life Science, 5: 280 – 283

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