Valentin Jossen

Position at the ZHAW

- Research Associate
- Deputy head of the Cell Culture Technology Group

www.zhaw.ch/icbt/bioverfahrenstechnik

Expertise and research interests

- Cell Culture Technique (mammalian cells, human stem cells)
- Computational Fluid Dynamics (CFD)
- Biochemical Engineering characterization and development of new bioreactor systems

Educational background

- Dr.-Ing. (Technical University of Berlin)
- Certificate of Advanced Studies in didactics (Zurich University of Education)
- M.Sc. Pharmaceutical Biotechnology (Zurich University of Applied Sciences)
- B.Sc. Biotechnology (Zurich University of Applied Sciences)

Membership of networks

• DECHEMA

• Muoio, Francesco; Panella, Stefano; Lindner, Matias; Jossen, Valentin; Harder, Yves; Moccetti, Tiziano; Eibl-Schindler, Regine ; Müller, Michele; Tallone, Tiziano,

  2021.

  Development of a biodegradable microcarrier for the cultivation of human adipose stem cells (hASCs) with a defined xeno- and serum-free medium .

  Applied Sciences.

  11(3),

  pp. 925.

  Available from : https://doi.org/10.3390/app11030925

• Seidel, Stefan ; Maschke, Rüdiger ; Werner, Sören ; Jossen, Valentin; Eibl, Dieter ,

  2020.

  Oxygen mass transfer in biopharmaceutical processes : numerical and experimental approaches  .

  Chemie Ingenieur Technik.

  93(1-2).

  Available from : https://doi.org/10.1002/cite.202000179

• Jossen, Valentin; Muoio, Francesco; Panella, Stefano; Harder, Yves; Tallone, Tiziano; Eibl-Schindler, Regine ,

  2020.

  An approach towards a GMP compliant in-vitro expansion of human adipose stem cells for autologous therapies .

  Bioengineering.

  7(3),

  pp. 77.

  Available from : https://doi.org/10.3390/bioengineering7030077

• Jossen, Valentin; Eibl-Schindler, Regine ; Kraume, Matthias; Eibl, Dieter ,

  2018.

  Growth behavior of human adipose tissue-derived stromal/stem cells at small scale : numerical and experimental investigations .

  Bioengineering.

  5(4),

  pp. 106.

  Available from : https://doi.org/10.3390/bioengineering5040106

• Eibl-Schindler, Regine ; Jossen, Valentin; Eibl, Dieter ,

  2018.

  Einweg-Bioreaktoren : therapeutische Antikörper .

  Chemie in unserer Zeit.

  52(4),

  pp. 230-237.

  Available from : https://doi.org/10.1002/ciuz.201800803

• Jossen, Valentin; van den Bos, Christian; Eibl-Schindler, Regine ; Eibl, Dieter ,

  2018.

  Manufacturing human mesenchymal stem cells at clinical scale : process and regulatory challenges .

  Applied Microbiology and Biotechnology.

  102(9),

  pp. 3981-3994.

  Available from : https://doi.org/10.1007/s00253-018-8912-x

• Kaiser, Stephan C.; Werner, Sören ; Jossen, Valentin; Kraume, Matthias; Eibl, Dieter ,

  2017.

  Development of a method for reliable power input measurements in conventional and single-use stirred bioreactors at laboratory scale .

  Engineering in Life Sciences.

  17(5),

  pp. 500-511.

  Available from : https://doi.org/10.1002/elsc.201600096

• Demuth, Caspar ; Varonier, Joel; Jossen, Valentin; Eibl-Schindler, Regine ; Eibl, Dieter ,

  2016.

  Novel probes for pH and dissolved oxygen measurements in cultivations from millilitre to benchtop scale .

  Applied Microbiology and Biotechnology.

  100(9),

  pp. 3853-3863.

  Available from : https://doi.org/10.1007/s00253-016-7412-0

• Jossen, Valentin; Schirmer, Cedric ; Mostafa Sindi, Dolman ; Eibl-Schindler, Regine ; Kraume, Matthias ; Pörtner, Ralf; Eibl, Dieter ,

  2016.

  Theoretical and practical issues that are relevant when scaling up hMSC microcarrier production processes .

  Stem Cells International.

  2016(4760414).

  Available from : https://doi.org/10.1155/2016/4760414

• Schirmaier, Carmen; Jossen, Valentin; Kaiser, Stephan C. ; Jüngerkeks, Frank; Silke, Brill; Safavi-Nab, Agnieszka; Siehoff, Ann; van den Bos, Christian; Eibl, Dieter ; Eibl-Schindler, Regine ,

  2014.

  Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions .

  Engineering in Life Sciences.

  14(3),

  pp. 292-303.

  Available from : https://doi.org/10.1002/elsc.201300134

• Jossen, Valentin; Kaiser, Stephan C.; Schirmaier, Carmen; Hermann, Jacqueline ; Tappe, Alexander ; Eibl, Dieter ; Siehoff, Ann; van den Bos, Christian; Eibl-Schindler, Regine ,

  2014.

  Modification and qualification of a stirred single-use bioreactor for the improved expansion of human mesenchymal stem cells at benchtop scale .

  Pharmaceutical Bioprocessing.

  2(4),

  pp. 311-322.

• Kaiser, Stephan; Jossen, Valentin; Schirmaier, Carmen; Eibl, Dieter ; Brill, Silke; van den Bos, Christian; Eibl-Schindler, Regine ,

  2013.

  Fluid flow and cell proliferation of mesenchymal adipose-derived stem cells in small-scale, stirred, single-use bioreactors .

  Chemie Ingenieur Technik.

  85(1-2),

  pp. 95-102.

  Available from : https://doi.org/10.1002/cite.201200180

• Jossen, Valentin; Eibl-Schindler, Regine ; Pörtner, Ralf; Kraume, Matthias; Eibl, Dieter ,

  2017.

  Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes

  .

  In:

  Current Developments in Biotechnology and Bioengineering.

  Elsevier.

  pp. 179-215.

  Available from : https://doi.org/10.1016/B978-0-444-63663-8.00007-0

• Maschke, Rüdiger ; Werner, Sören ; Stalder, Mischa; Jossen, Valentin; Eibl, Dieter ,

  2016.

  Nutzung von Sensor Spots zur Bestimmung der Gelöstsauerstoffkonzentration in Single-use Systemen im Labormassstab [ poster ].

  In:

  Institut für Bioprozess- und Analysenmesstechnik, ed. ,

  Tagungsband.

  18. Heiligenstädter Kolloquium "Technische Systeme für die Lebenswissenschaft", Heilbad Heiligenstadt, 19.-21. September 2016.

  Winterthur:

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Available from : https://doi.org/10.21256/zhaw-1152

• van den Bos, Christian; Jossen, Valentin; Eibl, Dieter ; Eibl-Schindler, Regine ,

  2019.

  Advanced therapy medicinal products (ATMPs) & GMP : 10 years after .

  Die Pharmazeutische Industrie : pharmind.

  81(4),

  pp. 508-513.

• Jossen, Valentin; Schirmaier, Carmen; John, Gernot T.; Eibl, Dieter ; Eibl-Schindler, Regine ,

  2015.

  On-line-pH- und -DO-Messungen in Mikrocarrier-basierter hMSC Kultur .

  BIOspektrum.

  21(4),

  pp. 422-424.

  Available from : https://doi.org/10.1007/s12268-015-0597-4

• Jossen, Valentin; Pörtner, Ralf ; Kaiser, Stephan C. ; Kraume, Matthias; Eibl, Dieter ; Eibl-Schindler, Regine ,

  2014.

  Mass production of mesenchymal stem cells — impact of bioreactor design and flow conditions on proliferation and differentiation

  .

  In:

  Eberli, Daniel, ed. ,

  Cells and Biomaterials in Regenerative Medicine.

  InTech.

  pp. 119-172.

  Tissue Engineering and Regenerative Medicine.

  Available from : https://doi.org/10.5772/59385

• Jossen, Valentin; Schirmer, Cedric ; Eibl-Schindler, Regine ; Kraume, Matthias; Pörtner, Ralf,

  2017.

  Standardized expansion of human adipose tissue-derived stromal/stem cells (hASCs) in wave-mixed single-use bioreactors with one-dimensional motion .

  In:

  ECI: Single Use Technologies II: Bridging Polymer Science to Bioprocess Applications, Tomar, Portugal, 7–10 May 2017.

  Available from : https://pdfs.semanticscholar.org/9a61/98bcd2e950104f1457e8f0e7c7380323ebf5.pdf

• Schirmer, Cedric ; Jossen, Valentin; Mostafa Sindi, Dolman; Eibl-Schindler, Regine ; Böttcher, Lars; Eibl, Dieter ,

  2016.

  Standardized expansion of human mesenchymal stem cells in wave-mixed single-use bioreactors .

  In:

  ILMAC, Basel, 2016.

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