Valentin Jossen

Position at the ZHAW

Research Associate

www.zhaw.ch/icbt/bioverfahrenstechnik

Expertise and research interests

Computational Fluid Dynamics CFD, Particle Image Velocimetry PIV, Cell Culture Technique, Human mesenchymal stem cells, Animal Cells

Educational background

Study Biotechnology, M. Sc., 2014, Zurich University of Applied Sciences

Membership of networks

• DECHEMA

Articles in scientific journal, peer-reviewed

• Jossen, Valentin; Eibl-Schindler, Regine; Kraume, Matthias; Eibl, Dieter,

  2018.

  Growth behavior of human adipose tissue-derived stromal/stem cells at small scale : numerical and experimental investigations.

  Bioengineering.

  5(4),

  pp. 106.

  Available from: https://doi.org/10.21256/zhaw-19649

• Eibl-Schindler, Regine; Jossen, Valentin; Eibl, Dieter,

  2018.

  Einweg-Bioreaktoren : therapeutische Antikörper.

  Chemie in unserer Zeit.

  52(4),

  pp. 230-237.

  Available from: https://doi.org/10.1002/ciuz.201800803

• Jossen, Valentin; van den Bos, Christian; Eibl-Schindler, Regine; Eibl, Dieter,

  2018.

  Manufacturing human mesenchymal stem cells at clinical scale : process and regulatory challenges.

  Applied Microbiology and Biotechnology.

  102(9),

  pp. 3981-3994.

  Available from: https://doi.org/10.21256/zhaw-3135

• Kaiser, Stephan C.; Werner, Sören; Jossen, Valentin; Kraume, Matthias; Eibl, Dieter,

  2017.

  Development of a method for reliable power input measurements in conventional and single-use stirred bioreactors at laboratory scale.

  Engineering in Life Sciences.

  17(5),

  pp. 500-511.

  Available from: https://doi.org/10.21256/zhaw-19650

• Demuth, Caspar; Varonier, Joel; Jossen, Valentin; Eibl-Schindler, Regine; Eibl, Dieter,

  2016.

  Novel probes for pH and dissolved oxygen measurements in cultivations from millilitre to benchtop scale.

  Applied Microbiology and Biotechnology.

  100(9),

  pp. 3853-3863.

  Available from: https://doi.org/10.21256/zhaw-1584

• Jossen, Valentin; Schirmer, Cedric; Mostafa Sindi, Dolman; Eibl-Schindler, Regine; Kraume, Matthias; Pörtner, Ralf; Eibl, Dieter,

  2016.

  Theoretical and practical issues that are relevant when scaling up hMSC microcarrier production processes.

  Stem Cells International.

  2016(4760414).

  Available from: https://doi.org/10.21256/zhaw-1592

• Schirmaier, Carmen; Jossen, Valentin; Kaiser, Stephan C.; Jüngerkeks, Frank; Silke, Brill; Safavi-Nab, Agnieszka; Siehoff, Ann; van den Bos, Christian; Eibl, Dieter; Eibl-Schindler, Regine,

  2014.

  Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions.

  Engineering in Life Sciences.

  14(3),

  pp. 292-303.

  Available from: https://doi.org/10.1002/elsc.201300134

• Jossen, Valentin; Kaiser, Stephan C.; Schirmaier, Carmen; Hermann, Jacqueline; Tappe, Alexander; Eibl, Dieter; Siehoff, Ann; van den Bos, Christian; Eibl-Schindler, Regine,

  2014.

  Modification and qualification of a stirred single-use bioreactor for the improved expansion of human mesenchymal stem cells at benchtop scale.

  Pharmaceutical Bioprocessing.

  2(4),

  pp. 311-322.

• Kaiser, Stephan; Jossen, Valentin; Schirmaier, Carmen; Eibl, Dieter; Brill, Silke; van den Bos, Christian; Eibl-Schindler, Regine,

  2013.

  Fluid flow and cell proliferation of mesenchymal adipose-derived stem cells in small-scale, stirred, single-use bioreactors.

  Chemie Ingenieur Technik.

  85(1-2),

  pp. 95-102.

  Available from: https://doi.org/10.1002/cite.201200180

Book parts, peer-reviewed

• Jossen, Valentin; Eibl-Schindler, Regine; Pörtner, Ralf; Kraume, Matthias; Eibl, Dieter,

  2017.

  Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes

  .

  In:

  Current Developments in Biotechnology and Bioengineering.

  Elsevier.

  pp. 179-215.

  Available from: https://doi.org/10.1016/B978-0-444-63663-8.00007-0

Conference contributions, peer-reviewed

• Maschke, Rüdiger; Werner, Sören; Stalder, Mischa; Jossen, Valentin; Eibl, Dieter,

  2016.

  Nutzung von Sensor Spots zur Bestimmung der Gelöstsauerstoffkonzentration in Single-use Systemen im Labormassstab [poster].

  In:

  Institut für Bioprozess- und Analysenmesstechnik, ed.,

  Tagungsband.

  18. Heiligenstädter Kolloquium "Technische Systeme für die Lebenswissenschaft", Heilbad Heiligenstadt, 19.-21. September 2016.

  Winterthur:

  ZHAW Zürcher Hochschule für Angewandte Wissenschaften.

  Available from: https://doi.org/10.21256/zhaw-1152

Other publications

• van den Bos, Christian; Jossen, Valentin; Eibl, Dieter; Eibl-Schindler, Regine,

  2019.

  Advanced therapy medicinal products (ATMPs) & GMP : 10 years after.

  Die Pharmazeutische Industrie : pharmind.

  81(4),

  pp. 508-513.

• Jossen, Valentin; Schirmaier, Carmen; John, Gernot T.; Eibl, Dieter; Eibl-Schindler, Regine,

  2015.

  On-line-pH- und -DO-Messungen in Mikrocarrier-basierter hMSC Kultur.

  BIOspektrum.

  21(4),

  pp. 422-424.

  Available from: https://doi.org/10.21256/zhaw-1590

• Jossen, Valentin; Pörtner, Ralf; Kaiser, Stephan C.; Kraume, Matthias; Eibl, Dieter; Eibl-Schindler, Regine,

  2014.

  Mass production of mesenchymal stem cells — impact of bioreactor design and flow conditions on proliferation and differentiation

  .

  In:

  Eberli, Daniel, ed.,

  Cells and Biomaterials in Regenerative Medicine.

  InTech.

  pp. 119-172.

  Tissue Engineering and Regenerative Medicine.

  Available from: https://doi.org/10.21256/zhaw-1597

Oral conference contributions and abstracts

• Jossen, Valentin; Schirmer, Cedric; Eibl-Schindler, Regine; Kraume, Matthias; Pörtner, Ralf,

  2017.

  Standardized expansion of human adipose tissue-derived stromal/stem cells (hASCs) in wave-mixed single-use bioreactors with one-dimensional motion.

  In:

  ECI: Single Use Technologies II: Bridging Polymer Science to Bioprocess Applications, Tomar, Portugal, 7–10 May 2017.

  Available from: https://pdfs.semanticscholar.org/9a61/98bcd2e950104f1457e8f0e7c7380323ebf5.pdf

• Schirmer, Cedric; Jossen, Valentin; Mostafa Sindi, Dolman; Eibl-Schindler, Regine; Böttcher, Lars; Eibl, Dieter,

  2016.

  Standardized expansion of human mesenchymal stem cells in wave-mixed single-use bioreactors.

  In:

  ILMAC, Basel, 2016.

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