Dr. Michael Brand

Personal profile

Position at the ZHAW

www.zhaw.ch/icbt/organische-und-medizinische-chemie/

Projects

• Development of small-molecules targeting CD93-signaling for the treatment of leukemia / Team member / Project completed
• Burn Wound Treatment / Team member / Project completed
• Antivirale Wirkstoffe / Team member / Project completed
• MMP-Inhibitor-Hydrogel zur Wundheilung / Team member / Project completed
• New antileishmanial and antitrypanosomal drugs / Team member / Project completed

Publications

• Sabani, Besmira; Brand, Michael; Albert, Ina; Inderbitzin, Joelle; Eichenseher, Fritz; Schmelcher, Mathias; Rohrer, Jack; Riedl, Rainer; Lehmann, Steffi,

  2023.

  A novel surface functionalization platform to prime extracellular vesicles for targeted therapy and diagnostic imaging.

  Nanomedicine: Nanotechnology, Biology and Medicine.

  47(102607).

  Available from: https://doi.org/10.1016/j.nano.2022.102607

• Brand, Michael; Bommeli, Elias Benjamin; Rütimann, Marc; Lindenmann, Urs; Riedl, Rainer,

  2022.

  Discovery of a dual SENP1 and SENP2 inhibitor.

  International Journal of Molecular Sciences.

  23(20), pp. 12085.

  Available from: https://doi.org/10.3390/ijms232012085

• Brand, Michael; Wang, Lei; Agnello, Stefano; Gazzola, Silvia; Gall, Flavio; Raguž, Luka; Kaiser, Marcel; Schmidt, Remo S.; Ritschl, Amélie; Jelk, Jennifer; Hemphill, Andrew; Mäser, Pascal; Bütikofer, Peter; Adams, Michael; Riedl, Rainer,

  2021.

  Antiprotozoal structure–activity relationships of synthetic leucinostatin derivatives and elucidation of their mode of action.

  Angewandte Chemie: International Edition.

  60(28), pp. 15613-15621.

  Available from: https://doi.org/10.1002/anie.202102153

• Brand, Michael; Wang, Lei; Agnello, Stefano; Gazzola, Silvia; Gall, Flavio; Raguž, Luka; Kaiser, Marcel; Schmidt, Remo S.; Ritschl, Amélie; Jelk, Jennifer; Hemphill, Andrew; Mäser, Pascal; Bütikofer, Peter; Adams, Michael; Riedl, Rainer,

  2021.

  Antiprotozoische Struktur‐Aktivitäts‐Beziehungen von synthetischen Leucinostatin‐Derivaten und Aufklärung ihres Wirkprinzips.

  Angewandte Chemie.

  133(28), pp. 15741-15749.

  Available from: https://doi.org/10.1002/ange.202102153

• Lindenmann, Urs; Brand, Michael; Gall, Flavio; Frasson, David; Hunziker, Lukas; Kroslakova, Ivana; Sievers, Martin; Riedl, Rainer,

  2020.

  Discovery of a class of potent and selective non‐competitive sentrin‐specific protease 1 inhibitors.

  ChemMedChem.

  15(8), pp. 675-679.

  Available from: https://doi.org/10.1002/cmdc.202000067

• Agnello, Stefano; Brand, Michael; Chellat, Mathieu; Gazzola, Silvia; Riedl, Rainer,

  2018.

  A Structural view on medicinal chemistry strategies against drug resistance.

  Angewandte Chemie.

  58(11), pp. 3300-3345.

  Available from: https://doi.org/10.1002/anie.201802416

• Agnello, Stefano; Brand, Michael; Chellat, Mathieu; Gazzola, Silvia; Riedl, Rainer,

  2018.

  Eine strukturelle Evaluierung medizinalchemischer Strategien gegen Wirkstoffresistenzen.

  Angewandte Chemie.

  131(11), pp. 3336-3383.

  Available from: https://doi.org/10.1002/ange.201802416

• Riedl, Rainer; Brand, Michael,

  2012.

  Synthese und medizinalchemische Optimierung von Tetrazyklinanaloga.

  À Jour: SVC - Chemie, Life Sciences & Biotechnologie.

  2012(1), pp. 10-11.

• Riedl, Rainer; Fischer, Thomas; Züger, Patrik; Brand, Michael,

  2011.

  Structure based design and synthesis of novel MMP inhibitors [poster].

  In:

  Fall Meeting 2011 of the Swiss Chemical Society, Lausanne, 9 September 2011.

• Riedl, Rainer; Brand, Michael; Sephton, Mark,

  2011.

  Synthesis of tetracycline analogues [poster].

  In:

  Fall Meeting 2011 of the Swiss Chemical Society, Lausanne, 9 September 2011.

Patents and patent applications

• So, Alexander; Busso, Natalie; Nasi, Sonia; Brand, Michael; Gall, Flavio Max; Riedl, Rainer; Germann, Stefan,

  2022.

  Methods and compositions for treating conditions associated with hypermineralization.

  Patent number WO2022194953 A1

  (2022-09-22)

  .

  Available from: https://worldwide.espacenet.com/patent/search?q=pn%3DWO2022194953A1

• Schneider, Peter; Riedl, Rainer; Tigges, Marcel; Gitzinger, Marc; Pieren, Michel; Levi, Assaf; Sephton, Mark; Schellhorn, Birgit; Züger, Patrik; Brand, Michael; Gygax, Daniel; Spies, Peter,

  2015.

  Composition for treatment of pathogens that are resistant to tetracyclines.

  Patent number EP2950793 A1

  (2015-12-09)

  .

  Available from: https://worldwide.espacenet.com/patent/search?q=pn%3DEP2950793A1

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