TEDD Visit: University of Zurich Department of Pathology and Molecular Pathology

Name: TEDD Visit: University of Zurich Department of Pathology and Molecular Pathology
Start: 2023-06-07T10:15:00+02:00
End: 2023-06-07T14:45:00+02:00

7. Juni 2023

The mission is to support clinicians to better guide the individual cancer therapy for our patients. In order to do so, we use high fidelity patient derived ex vivo models of solid cancers to identify the effects of tumor specific factors upon oncogenic signalling, identify novel targets and treatment strategies with high efficacy.

EVENT FOCUS

Our Clinical Activities

Our main focus is the development of high-fidelity patient-derived ex-vivo cancer models for functional precision oncology. With such an approach, we can complement static features by generating dynamic data that may encompass key vulnerabilities, including those conveyed by altered signalling pathways due to, for example, epigenetic changes not necessarily driven by distinct genomic aberrations.

Our functional precision oncology platforms integrate functional testing with comprehensive genomics, transcriptomics and clinical data in order to find druggable targets, redefine the standard of patient care, and improve patient outcomes.

Our Research Activities

Our research activities encompass medium to high throughput drug screening and CRISPR/Cas9 technologies on ex-vivo patient derived cancer models for the discovery and identification of novel drug targets an drug vulnerabilities in especially rare cancers such as soft tissue sarcomas and cancers that are difficult to treat (e.g. pancreatic cancer). We study the environmental influences on drug responses using different hydrogels. With the establishment of resistant patient-derived ex-vivo cancer cell models, we obtain insight into the mechanism of acquired drug resistance. Together with our collaborators, we further pursue projects using cutting-edge machine learning algorithms to better predict drug responses in patient-derived ex-vivo cancer models.

Group's Website

PROGRAM - See full program(PDF 240,0 KB)

10:15 - 10:45 Registration & Coffee
10:45 – 11:00 Welcome by Chantal Pauli and Markus Rimann
11:00 – 11:15 Talk 1: Functional Precision Oncology – A Clinical Approach
11:15 – 11:45 Talk 2: Science Pitches from the Laboratory of Systems Pathology and Functional Tumor Pathology.
11:45 – 12:00 Group photo
12:00 - 13:15 Lunch
13:15 – 14:30 Lab Tour (two-three groups of 10 - 15 minutes)
14:30 – 14:45 Closing words, Chantal & Markus