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CCBIO Publication featured on the Front Cover of the Journal “Angewandte Chemie”

A recent work by the CCBIO-group on the use of engineered squalene-hopene cyclases for the synthesis of fragrance molecules is featured on the front cover of “Angewandte Chemie”.

Cover of Angewandte Chemie 2021, 60 (50)
Cover of Angewandte Chemie 2021, 60 (50)

Pure isomers of ionones are important molecules for the fragrance industry. In particular, α-Ambrinol is on demand due to a woody, tobacco- and musk-like smell. The natural (S)-(+)-γ-dihydroionone is isolated for example from Ambergris a waxy substance produced by the digestive system of sperm whales. Our publication in “Angewandte Chemie” describes an enzymatic approach for the synthesis of this compound.

Asymmetric Cation-Olefin Monocyclization by Engineered Squalene-Hopene Cyclases

M. Eichenberger, S. Hüppi, D. Patsch, N. Aeberli, R. Berweger, S. Dossenbach, E. Eichhorn, F. Flachsmann, L. Hortencio, F. Voirol, S. Vollenweider, U. Bornscheuer, R. Buller. Angewandte Chemie. 04 August 4, 2021. https://doi.org/10.1002/anie.202108037